Akụkọ

A na-akpọkwa peptide ọla kọpaGHK-cubụ mgbagwoju kpụrụ site Nchikotatripeptide - 1na ọla kọpa ion.Nchọpụta nyocha na-egosi na ọla kọpa dị n'ahụ anụmanụ na-arụ ọrụ dị mkpa n'ụzọ dị iche iche, ọkachasị site na mmetụta ọla kọpa na enzymes antioxidant.Enwere ọtụtụ enzymes dị mkpa na ahụ mmadụ na akpụkpọ ahụ chọrọ ion ọla kọpa.Enzymes ndị a na-ekere òkè na nhazi anụ ahụ njikọ, mgbochi oxidation na respiration cell.Ọla kọpa na-arụkwa ọrụ dị ịrịba ama, nke nwere ike imetụta omume na metabolism nke mkpụrụ ndụ.Mgbe peptide ọla kọpa soluble na mmiri, ọ na-egosi na agba eze-acha anụnụ anụnụ nke na-akpọ Blue ọla kọpa peptide na ulo oru ubi.

Nnyocha na-egosi na peptide ọla kọpa nwere ọtụtụ uru maka nlekọta anụ ahụ, nke nwere nnukwu ngwa nwere ike na ụlọ ọrụ ịchọ mma.

1. Ọrụ nke peptide ọla kọpa na imegharị akpụkpọ ahụ

Nnyocha ahụ na-egosi peptide ọla kọpa na-emezigharị metalloproteinases dị iche iche na usoro nrụgharị anụ ahụ oke.Ọrụ nke enzyme ahụ na-akwalite nbibi nke protein matrix extracellular, nke nwere ike ime ka nrụrụ nke protein matrix extracellular (protein ECM) na-egbochi mmebi akpụkpọ ahụ gabigara ókè.Peptide ọla kọpa na-abawanye proteoglycan bụ isi.Ọrụ nke proteoglycan a bụ igbochi nguzobe nke scars ma belata ọkwa nke na-agbanwe uto uto (TGF beta), nke na-abawanye scars site na ịhazi mgbakọ nke collagen fibrils.

2. Na-akpali njikọ nke collagen

Ọtụtụ nnwale ekwenyela na tripeptide-1 na-akpali njikọ nke collagen, glycosaminoglycan nhọrọ na obere protein glycan deproteinization.Na mgbakwunye, ọ nwekwara ike ịhazi njikọ nke metalloproteinases metụtara ya.Ụfọdụ n'ime enzymes ndị a ga-eme ka nbibi nke protein matrix extracellular, ebe ndị ọzọ nwere ike igbochi ọrụ protease.Nke a na-egosi na peptide ọla kọpa nwere ike ịhazi ọkwa protein dị na akpụkpọ ahụ.

3. Mgbochi mkpali na antioxidant

Achọpụtara na peptide ọla kọpa na-egbochi mbufụt site na ibelata ọkwa nke cytokines na-akpasu iwe dị ka TGF-beta na TNF-a na nnukwu oge.Tripeptide-1 na-ebelatakwa mmebi oxidative site n'ịhazi ọkwa ígwè na imenyụ ngwaahịa na-egbu egbu nke fatty acid lipid peroxidation.

4. Kwalite ọgwụgwọ ọnya

Ọtụtụ nchọpụta anụmanụ ekwenyela na peptide ọla kọpa na-acha anụnụ anụnụ nwere ike ịgwọ ọnya.N'ime nnwale oke bekee, peptide ọla kọpa na-acha anụnụ anụnụ nwere ike mee ka ọgwụgwọ ọnya dị ngwa ngwa, kwalite angiogenesis, na ịbawanye ọdịnaya nke enzymes antioxidant n'ime ọbara.

5. Weghachite ọrụ nke mkpụrụ ndụ mebiri emebi

Fibroblasts bụ mkpụrụ ndụ bụ isi nke ọgwụgwọ ọnya na imegharị anụ ahụ.Ọ bụghị nanị na ha na-ejikọta akụkụ dị iche iche nke matrix extracellular, kamakwa na-emepụta ọnụ ọgụgụ buru ibu nke ihe na-eto eto.Nnyocha e mere na 2005 gosiri na tripeptide-1 nwere ike iweghachi ikike nke fibroblasts na-egbuke egbuke.

Peptide ọla kọpa bụ ụdị polypeptide nwere ihe mgbochi ịka nká na nrụzi.Ọ bụghị nanị na ọ na-akwalite mmepụta nke ụdị I, IV na VII collagen, kamakwa ọ na-akwalite ọrụ nke collagen synthesis cell fibroblast, nke bụ ihe dị mma na-egbochi ịka nká.

N'ihe banyere nrụzi, peptide ọla kọpa nwere ike ichebe fibroblasts nke UV na-akpali, meziwanye ọrụ ha, belata nzuzo nke MMP-1, na-emeso ihe ndị na-akpasu iwe na-emepụta site na uche nke ọma, nọgide na-arụ ọrụ mgbochi akpụkpọ ahụ mebiri emebi n'ihi mkpali mpụga, ma nwee ezigbo mgbochi. ihe nfụkasị na ume ume.Peptide ọla kọpa na-ejikọta mgbochi ịka nká na nrụzi, nke dị ụkọ na ihe ndị na-egbochi ịka nká na nrụzi ugbu a.