Tacrolimus monohydrate 109581-93-3 ọgwụ nje
Ụgwọ:T/T, L/C
Isi mmalite ngwaahịa:China
Ọdụ ụgbọ mmiri:Beijing/Shanghai/Hangzhou
Ike mmepụta:1kg / ọnwa
Nye iwu (MOQ):1g
Etiti oge:3 ụbọchị ọrụ
Ọnọdụ nchekwa:Echekwara ya na ebe dị jụụ, ebe akọrọ, okpomọkụ ụlọ.
Ihe ngwugwu:vial, karama
Nha ngwugwu:1g / vial, 5/vial, 10g / vial, 50g / karama, 500g / karama
Ozi nchekwa:UN 2811 6.1/PG 3
Okwu mmalite
Tacrolimus, bụ ọgwụ mgbochi mgbochi.Mgbe a na-atụgharị akụkụ ahụ allogeneic, ihe ize ndụ nke ịjụ akụkụ ahụ dị oke.Iji belata ihe ize ndụ nke ịjụ akụkụ ahụ, a na-enye tacrolimus.A pụkwara ire ọgwụ ahụ dị ka ọgwụ n'elu n'elu ọgwụgwọ nke ọrịa ndị na-akpata T-cell dị ka eczema na psoriasis.Enwere ike iji ya gwọọ ọrịa anya nkụ na nwamba na nkịta.
Tacrolimus na-egbochi calcineurin, nke na-etinye aka na mmepụta nke interleukin-2, molecule nke na-akwalite mmepe na mmụba nke mkpụrụ ndụ T, dịka akụkụ nke mmeghachi omume mgbochi nke anụ ahụ mụtara (ma ọ bụ mgbanwe).
Nkọwapụta (USP43)
| Ihe | Nkọwapụta |
| Ọdịdị | Ọcha ma ọ bụ ọ fọrọ nke nta ka ọ bụrụ ntụ ntụ crystalline ọcha |
| njirimara | IR, HPLC |
| Solubility | Soluble nke ukwuu na methanol, soluble kpamkpam na N,N dimethylformamide na mmanya na-aba n'anya, ihe fọrọ nke nta ka ọ bụrụ na soluble na mmiri. |
| Ihe fọdụrụ na mgbanye | ≤0.10% |
| Organic adịghị ọcha (usoro-2) | Ascomycin 19-epimer ≤0.10% |
| Ascomycin ≤0.50% | |
| Desmethyl tacrolimus ≤0.10% | |
| Tacrolimus 8-epimer ≤0.15% | |
| Analọgụ Tacrolimus 8-propyl ≤0.15% | |
| Adịghị ọcha amaghi ama -I ≤0.10% | |
| Adịghị ọcha amaghi ama -II ≤0.10% | |
| Adịghị ọcha amaghi ama -III ≤0.10 % | |
| Mkpokọta adịghị ọcha ≤1.00 % | |
| Ntugharị anya (dị ka ndabere) (10mg/ml in N, Ndimethylformamide) | -110.0° ~ -115.0° |
| Ọdịnaya mmiri (nke KF) | ≤4.0% |
| Ihe mgbaze fọdụrụ (nke GC) | Acetone ≤1000ppm (n'ime ụlọ) |
| Di-isopropyl ether ≤100ppm (N'ime ụlọ) | |
| Ethyl ether ≤5000ppm | |
| Acetonitrile ≤410ppm | |
| Toluene ≤890ppm | |
| Hexane ≤290ppm | |
| Nnwale microbial (n'ime ụlọ) | Ngụkọta ọnụ ọgụgụ microbial aerobic ≤100cfu/gm |
| Ngụkọta yist na ebu bụ ≤10cfu/gm | |
| Ihe dị iche iche akọwapụtara (Pathogens) (E.coil, salmonella sps., S.aureus. Pseudomonas aeruginosa) ekwesịghị ịpụ. | |
| Nyocha (nke HPLC) (na anhydrous na ihe mgbaze n'efu) | 98% ~ 102% |
