Orlistat 96829-58-2 Mgbakwụnye nri oke ibu
Ụgwọ:T/T, L/C
Isi mmalite ngwaahịa:China
Ọdụ ụgbọ mmiri:Beijing/Shanghai/Hangzhou
Ike mmepụta:800kg / ọnwa
Nye iwu (MOQ):25kg
Etiti oge:3 ụbọchị ọrụ
Ọnọdụ nchekwa:Echekwara ya na ebe dị jụụ, ebe akọrọ, okpomọkụ ụlọ.
Ihe ngwugwu:drum
Nha ngwugwu:25kg / agba
Ozi nchekwa:Ọ bụghị ngwongwo dị ize ndụ
Okwu mmalite
Orlistat bụ ihe mgbochi lipase nke eriri afọ na-eme ogologo oge ma dị ike.Ọ na-acha ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ na-acha ọcha ntụ ntụ na ọnụ ụlọ okpomọkụ, nke a na-apụghị ịsacha na mmiri, na-agbaze na chloroform, na-adịkwa mfe soluble na ethanol.Ọ na-eme ka enzyme ahụ ghara ịrụ ọrụ site na ịmepụta njikọ covalent na saịtị serine na-arụ ọrụ nke lipase gastric na pancreatic lipase na afọ na obere eriri afọ.
Orlistat bụ ụdị ọgwụ lipase na-egbochi ibu ibu.Ọ bụ ihe na-emepụta mmiri nke lipstatin, nke nwere ike ibelata nnabata abụba nri ma belata ibu.Ngwaahịa a nwere mgbochi siri ike na nhọrọ nke lipase gastric na pancreatic lipase, enweghị mmetụta na enzymes digestive ndị ọzọ (amylase, trypsin, chymotrypsin) na phospholipase, na anaghị emetụta absorption nke carbohydrates, protein na phospholipids.Ọ na-egbochi enzyme ahụ tumadi site na njikọta covalent na serine residues na saịtị na-arụ ọrụ nke gastric lipase na pancreatic lipase na eriri afọ, na-egbochi hydrolysis nke triacylglycerol, na-ebelata oriri nke monoglyceride na fatty acid n'efu, wee si otú a na-achịkwa ibu ahụ.A naghị etinye ọgwụ ahụ na tract gastrointestinal, na mgbochi nke lipase na-agbanwe agbanwe.
Ngwaahịa a nwekwara ọrụ nke ịhazi lipids ọbara.Ọ nwere ike ibelata triglyceride na cholesterol lipoprotein dị obere n'ime ọbara nke ndị ọrịa buru ibu ma na-abawanye nha nke lipoprotein dị elu na lipoprotein dị obere.
Mgbe orlistat jikọtara ya na nri kalori dị ala, ọ dabara maka ọgwụgwọ ogologo oge nke ndị buru oke ibu na ndị buru oke ibu, gụnyere ndị mepụtara ihe ndị metụtara oke ibu.Ọ nwere ọrụ njikwa ibu dị ogologo oge dị ka mbelata ibu, mmezi arọ na mgbochi nlọghachi.Ụlọ ọgwụ na-egosi n'ụzọ doro anya na ọrụ njikwa ibu dị oke uru maka iji ogologo oge eme ihe mgbe ụlọ ọrụ na-eri nri ma ọ bụ mgbe otu awa gasịrị nri.
Orlistat nwere ike ibelata ọnụego ihe egwu metụtara oke ibu yana ọrịa ndị ọzọ metụtara oke ibu, gụnyere hypercholesterolemia, ụdị ọrịa shuga II, nnabata glucose na-adịghị mma, hyperinsulinemia, ọbara mgbali elu, ma belata ọdịnaya abụba na akụkụ ahụ.
Nkọwapụta (USP42)
| Ihe | Nkọwapụta |
| njirimara | HPLC, IR |
| Ntụgharị anya pụrụ iche | -48.0°~-51.0° |
| Ọdịnaya mmiri | ≤0.2% |
| Ihe ndị emetụtara I | Ngwakọta metụtara Orlistat A ≤0.2% |
| Ihe ndị metụtara II | Ngwakọta metụtara Orlistat B ≤0.05% |
| Ihe ndị metụtara III
| Formylleucine ≤0.2% |
| Ngwakọta metụtara Orlistat C ≤0.05% | |
| Orlistat oghere epimer ≤0.2% | |
| D-Leucine orlistat ≤0.2% | |
| Ihe adịghị ọcha nke onwe onye amataghị ≤0.1% | |
| Ihe ndị metụtara IV | Ngwakọta metụtara Orlistat D ≤0.2% |
| Orlistat meghere mgbanaka amide ≤0.1% | |
| Ihe ndị emetụtara V | Ngwakọta metụtara Orlistat E ≤0.2% |
| Mkpokọta adịghị ọcha (I ruo V) | ≤1.0% |
| Ihe mgbaze fọdụrụnụ | Methanol ≤0.3% |
| EtOAc ≤0.5% | |
| n-Heptane ≤0.5% | |
| Ihe fọdụrụ na mgbanye | ≤0.1% |
| Ọla dị arọ dị ka Pb | ≤20ppm |
| Nyocha sitere na HPLC | 98.0% ~ 101.5% (na anhydrous, ihe mgbaze na-enweghị ndabere) |
